Cancer Pain – Pipeline Review, H2 2013

145 pages report Published in
Pharmaceuticals
Publisher: Global Markets Direct

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Cancer Pain – Pipeline Review, H2 2013

Summary

Global Markets Direct’s, ‘Cancer Pain – Pipeline Review, H2 2013’, provides an overview of the indication’s therapeutic pipeline. This report provides information on the therapeutic development for Cancer Pain, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Cancer Pain. Cancer Pain – Pipeline Review, Half Year is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

– A snapshot of the global therapeutic scenario for Cancer Pain.

– A review of the Cancer Pain products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.

– Coverage of products based on various stages of development ranging from discovery till registration stages.

– A feature on pipeline projects on the basis of monotherapy and combined therapeutics.

– Coverage of the Cancer Pain pipeline on the basis of route of administration and molecule type.

– Key discontinued pipeline projects.

– Latest news and deals relating to the products.

Reasons to buy

– Identify and understand important and diverse types of therapeutics under development for Cancer Pain.

– Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage.

– Plan mergers and acquisitions effectively by identifying players of the most promising pipeline.

– Devise corrective measures for pipeline projects by understanding Cancer Pain pipeline depth and focus of Indication therapeutics.

– Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.

– Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline.

Table of Contents

Table of Contents 2

List of Tables 8

List of Figures 9

Introduction 10

Global Markets Direct Report Coverage 10

Cancer Pain Overview 11

Therapeutics Development 12

An Overview of Pipeline Products for Cancer Pain 12

Cancer Pain Therapeutics under Development by Companies 14

Cancer Pain Therapeutics under Investigation by Universities/Institutes 17

Late Stage Products 18

Comparative Analysis 18

Mid Clinical Stage Products 19

Comparative Analysis 19

Early Clinical Stage Products 20

Comparative Analysis 20

Discovery and Pre-Clinical Stage Products 21

Comparative Analysis 21

Cancer Pain Therapeutics - Products under Development by Companies 22

Cancer Pain Therapeutics - Products under Investigation by Universities/Institutes 24

Companies Involved in Cancer Pain Therapeutics Development 25

Kyowa Hakko Kirin Co., Ltd. 25

Amgen Inc. 26

BioDelivery Sciences International, Inc. 27

Daiichi Sankyo Company, Ltd 28

Sangamo BioSciences, Inc. 29

Egalet a/s 30

Alexza Pharmaceuticals, Inc. 31

Samyang Corporation 32

Aphios Corporation 33

AcelRx Pharmaceuticals, Inc. 34

Laboratoires Pierre Fabre SA 35

Nippon Kayaku Co., Ltd. 36

Nippon Shinyaku Co., Ltd. 37

Orion Corporation 38

Pfizer Inc. 39

Zeria Pharmaceutical Co Ltd 40

GW Pharmaceuticals plc 41

IntelGenx Technologies Corp. 42

Benitec Ltd. 43

NovaDel Pharma, Inc. 44

KOLON LIFE SCIENCE INC. 45

Diamyd Medical AB 46

BioAlliance Pharma SA 47

Labtec GmbH 48

Grunenthal GmbH 49

AngioChem Inc. 50

WEX Pharmaceuticals Inc. 51

QRxPharma Limited 52

APEIRON Biologics AG 53

Winston Pharmaceuticals, Inc. 54

Encore Therapeutics Inc. 55

Afferent Pharmaceuticals, Inc. 56

Cancer Pain - Therapeutics Assessment 57

Assessment by Monotherapy Products 57

Assessment by Combination Products 58

Assessment by Route of Administration 59

Assessment by Molecule Type 62

Drug Profiles 64

tanezumab - Drug Profile 64

Product Description 64

Mechanism of Action 64

R&D Progress 64

fentanyl - Drug Profile 67

Product Description 67

Mechanism of Action 67

R&D Progress 67

fentanyl - Drug Profile 69

Product Description 69

Mechanism of Action 69

R&D Progress 69

nabiximols - Drug Profile 70

Product Description 70

Mechanism of Action 70

R&D Progress 70

buprenorphine hydrochloride - Drug Profile 72

Product Description 72

Mechanism of Action 72

R&D Progress 72

dronabinol - Drug Profile 73

Product Description 73

Mechanism of Action 73

R&D Progress 73

fentanyl citrate - Drug Profile 74

Product Description 74

Mechanism of Action 74

R&D Progress 74

fentanyl citrate - Drug Profile 76

Product Description 76

Mechanism of Action 76

R&D Progress 76

Tetrodotoxin - Drug Profile 77

Product Description 77

Mechanism of Action 77

R&D Progress 77

ZFP Transcription Factors For Neuropathic Pain - Drug Profile 79

Product Description 79

Mechanism of Action 79

R&D Progress 79

(morphine + oxycodone) CR - Drug Profile 80

Product Description 80

Mechanism of Action 80

R&D Progress 80

ARX-02 - Drug Profile 81

Product Description 81

Mechanism of Action 81

R&D Progress 81

morphine sulfate ER - Drug Profile 83

Product Description 83

Mechanism of Action 83

R&D Progress 83

zucapsaicin - Drug Profile 84

Product Description 84

Mechanism of Action 84

R&D Progress 84

fulranumab - Drug Profile 86

Product Description 86

Mechanism of Action 86

R&D Progress 86

NP-2 - Drug Profile 88

Product Description 88

Mechanism of Action 88

R&D Progress 88

ANG-2002 - Drug Profile 90

Product Description 90

Mechanism of Action 90

R&D Progress 90

P2X3 Targeted Program - Drug Profile 91

Product Description 91

Mechanism of Action 91

R&D Progress 91

dexmedetomidine hydrochloride - Drug Profile 92

Product Description 92

Mechanism of Action 92

R&D Progress 92

tramadol hydrochloride SR - Drug Profile 94

Product Description 94

Mechanism of Action 94

R&D Progress 94

fentanyl - Drug Profile 95

Product Description 95

Mechanism of Action 95

R&D Progress 95

Z-360 - Drug Profile 96

Product Description 96

Mechanism of Action 96

R&D Progress 96

TK-641 - Drug Profile 98

Product Description 98

Mechanism of Action 98

R&D Progress 98

THA-901 - Drug Profile 99

Product Description 99

Mechanism of Action 99

R&D Progress 99

ddRNAi Program For Cancer-Associated Pain - Drug Profile 100

Product Description 100

Mechanism of Action 100

R&D Progress 100

APN-601 - Drug Profile 102

Product Description 102

Mechanism of Action 102

R&D Progress 102

tapentadol ER - Drug Profile 103

Product Description 103

Mechanism of Action 103

R&D Progress 103

leconotide - Drug Profile 106

Product Description 106

Mechanism of Action 106

R&D Progress 106

hydromorphone - Drug Profile 107

Product Description 107

Mechanism of Action 107

R&D Progress 107

buprenorphine hydrochloride ER - Drug Profile 108

Product Description 108

Mechanism of Action 108

R&D Progress 108

AF-353 - Drug Profile 109

Product Description 109

Mechanism of Action 109

R&D Progress 109

befiradol - Drug Profile 111

Product Description 111

Mechanism of Action 111

R&D Progress 111

NRT-12 - Drug Profile 112

Product Description 112

Mechanism of Action 112

R&D Progress 112

DD-04107 - Drug Profile 113

Product Description 113

Mechanism of Action 113

R&D Progress 113

QX-314 - Drug Profile 114

Product Description 114

Mechanism of Action 114

R&D Progress 114

ifenprodil - Drug Profile 115

Product Description 115

Mechanism of Action 115

R&D Progress 115

Calpastatin - Drug Profile 116

Product Description 116

Mechanism of Action 116

R&D Progress 116

Drug For Pancreatic Cancer Pain - Drug Profile 117

Product Description 117

Mechanism of Action 117

R&D Progress 117

KLS-2010 - Drug Profile 118

Product Description 118

Mechanism of Action 118

R&D Progress 118

XPG-110 - Drug Profile 119

Product Description 119

Mechanism of Action 119

R&D Progress 119

PGN-202 - Drug Profile 120

Product Description 120

Mechanism of Action 120

R&D Progress 120

Cancer Pain Therapeutics - Drug Profile Updates 121

Cancer Pain Therapeutics - Discontinued Products 136

Cancer Pain Therapeutics - Dormant Products 137

Cancer Pain - Product Development Milestones 138

Featured News & Press Releases 138

Sep 03, 2013: Galena Biopharma Initiates RELIEF Patient Registry for Abstral Sublingual Tablets 138

Jul 31, 2013: Hisamitsu Pharmaceutical Submits Application Seeking Approval for Additional Indication of Chronic Pain for Fentos Tape, a Transdermal Long-Acting Cancer Pain Relief Patch 139

Jul 29, 2013: BioDelivery Sciences Announces Regulatory Approval of ONSOLIS in Taiwan 139

May 09, 2013: Galena Biopharma Presents Data On Development Of TIRF REMS Program At American Pain Society 32nd Annual Scientific Meeting 139

May 09, 2013: Purdue Pharma To Present Data Regarding Long-Term Opioid Therapy At APS Annual Meeting 140

Apr 05, 2013: Phosphagenics Receives Approval To Conduct Clinical Study Of Oxycodone Patch At Royal Adelaide Hospital 141

Apr 03, 2013: GW Pharma Receives US Patent Allowance For Delivery Of Sativex Formulation 141

Feb 14, 2013: US Federal Court Validates Cephalon's Fentora Patents 142

Nov 13, 2012: Orexo Announces Submission Of New Drug Application For KW-2246 In Japan 142

Oct 15, 2012: BioDelivery Sciences Announces Launch Of Breakyl In EU 143

Appendix 144

Methodology 144

Coverage 144

Secondary Research 144

Primary Research 144

Expert Panel Validation 144

Contact Us 145

Disclaimer 145



List of Tables

Number of Products Under Development for Cancer Pain, H2 2013 12

Products under Development for Cancer Pain - Comparative Analysis, H2 2013 13

Number of Products under Development by Companies, H2 2013 15

Number of Products under Development by Companies, H2 2013 (Contd..1) 16

Number of Products under Investigation by Universities/Institutes, H2 2013 17

Comparative Analysis by Late Stage Development, H2 2013 18

Comparative Analysis by Mid Clinical Stage Development, H2 2013 19

Comparative Analysis by Early Clinical Stage Development, H2 2013 20

Comparative Analysis by Discovery and Pre-Clinical Stage Development, H2 2013 21

Products under Development by Companies, H2 2013 22

Products under Development by Companies, H2 2013 (Contd..1) 23

Products under Investigation by Universities/Institutes, H2 2013 24

Kyowa Hakko Kirin Co., Ltd., H2 2013 25

Amgen Inc., H2 2013 26

BioDelivery Sciences International, Inc., H2 2013 27

Daiichi Sankyo Company, Ltd, H2 2013 28

Sangamo BioSciences, Inc., H2 2013 29

Egalet a/s, H2 2013 30

Alexza Pharmaceuticals, Inc., H2 2013 31

Samyang Corporation, H2 2013 32

Aphios Corporation, H2 2013 33

AcelRx Pharmaceuticals, Inc., H2 2013 34

Laboratoires Pierre Fabre SA, H2 2013 35

Nippon Kayaku Co., Ltd., H2 2013 36

Nippon Shinyaku Co., Ltd., H2 2013 37

Orion Corporation, H2 2013 38

Pfizer Inc., H2 2013 39

Zeria Pharmaceutical Co Ltd, H2 2013 40

GW Pharmaceuticals plc, H2 2013 41

IntelGenx Technologies Corp., H2 2013 42

Benitec Ltd., H2 2013 43

NovaDel Pharma, Inc., H2 2013 44

KOLON LIFE SCIENCE INC., H2 2013 45

Diamyd Medical AB, H2 2013 46

Grunenthal GmbH, H2 2013 49

AngioChem Inc., H2 2013 50

WEX Pharmaceuticals Inc., H2 2013 51

QRxPharma Limited, H2 2013 52

APEIRON Biologics AG, H2 2013 53

Winston Pharmaceuticals, Inc., H2 2013 54

Encore Therapeutics Inc., H2 2013 55

Afferent Pharmaceuticals, Inc., H2 2013 56

Assessment by Monotherapy Products, H2 2013 57

Assessment by Combination Products, H2 2013 58

Assessment by Stage and Route of Administration, H2 2013 61

Assessment by Stage and Molecule Type, H2 2013 63

Cancer Pain Therapeutics - Drug Profile Updates 121

Cancer Pain Therapeutics - Discontinued Products 136

Cancer Pain Therapeutics - Dormant Products 137



List of Figures

Number of Products under Development for Cancer Pain, H2 2013 12

Products under Development for Cancer Pain - Comparative Analysis, H2 2013 13

Products under Development by Companies, H2 2013 14

Products under Investigation by Universities/Institutes, H2 2013 17

Late Stage Products, H2 2013 18

Mid Clinical Stage Products, H2 2013 19

Early Clinical Stage Products, H2 2013 20

Discovery and Pre-Clinical Stage Products, H2 2013 21

Assessment by Monotherapy Products, H2 2013 57

Assessment by Combination Products, H2 2013 58

Assessment by Route of Administration, H2 2013 59

Assessment by Stage and Route of Administration, H2 2013 60

Assessment by Molecule Type, H2 2013 62

Assessment by Stage and Molecule Type, H2 2013 63

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